The working objectives of this cluster are based on the AU and NEPAD priority areas and are consistent with the MDGs, the UN General Assembly Special Session on HIV/AIDS and the 2001 Abuja Declaration on HIV/AIDS, Tuberculosis, Malaria and other related diseases.
It has six sub–clusters:

• Health , HIV/AIDS, Malaria, TB and other infectious diseases;
• Education and Human Resources;
• Gender, Youth and Development;
• Social Welfare, Protection and Human Trafficking;
• Labour and Employment; and

• Sports and Culture

Coordinator: Ms. Judica Amri-Lawson, Senior Advisor, ILO
Co-Coordinator: Ms. Advocate Bience Gawanas, Commissioner for Social Affairs, AUC

Health, HIV/AIDS, Malaria, TB and other infectious diseases
The Sub-Cluster aims to combat HIV/AIDS, Malaria, TB and other infectious diseases, which are the major causes of morbidity and mortality as well as a constrain to the Social-Economic development agenda of  Africa.

Coordinator: Mrs. Rosemary Museminali, Representative to AU and UNECA, Joint United Nations Programme on HIV/AIDS (UNAIDS)
 Co-Coordinator:   Dr. Fatoumata Nafo-Troré, Representative to Ethiopia, World Health Organization (WHO)

Education and Human Resources (EHRSC):
The Sub-cluster (EHRSC) aims to provide concerted support to the AU and its NEPAD program in the areas of education and youth for advancing social, human, and educational development in Africa with a specific focus on the implementation of the Second Decade of Education for Africa Plan of Action (2006-2015) and the Africa Decade for Youth Development and Empowerment (2009-2018).

Coordinator: Mr. Alexandros Makarigakis, OIC , United Nations Educational, Scientific and Cultural Organization(UNESCO)
Co-Coordinator: Ms. Beatrice Khamati Njenga, Head, Division of Education, AUC

Gender and Development:
The goal of this Sub-cluster is promoting gender equality and the empowerment of women. Further strengthening NEPAD’s priority areas is also the objective of the Sub-cluster.
Coordinator: Ms. Florence Butegwa, Representative of UN Women to AU/ECA, UN Women
Co-Coordinator: Ms. Litha Musyimi Ogana, Director of Women and Gender Development, AUC 

Social Welfare, Protection and Human Trafficking:
The Sub-cluster aims to tackle social welfare, protection and human trafficking by  promoting NEPAD priority area of Human Resources Development including Reversing the Brain Drain,  it  provides technical support to African countries in establishing programmes for reversing the brain drain.
 Coordinator: Mr.Josiah Ogina, Head of Mission, IOM
 Co-Coordinator:  Mr. Olawale Mayeigun, Director of Department of Social Affairs, AUC  

Labour and Employment
Provides the much needed support for the implementation of 2004 Ouagadougou Declaration and Plan of Action adopted by the AU Extraordinary Summit (2004).
 Coordinator: Judica Amri-Lawson, Senior Advisor, ILO
 Co-Coordinator: Mr. Oumar Diop , Senior Policy Officer African Union Commission (AUC)

Sports and Culture
The Sports and Culture Sub Cluster aims to provide concerted support to the AU and its NEPAD programme in the area of culture and sports for advancing social, cultural, and human development in Africa.

 Coordinator: Mr. Marcellin Dally, Regional Advisor for Africa Sport & PE United Nations Educational, Scientific and Cultural Organization (UNESCO)
 Co-Coordinator:   Mr. Johan Strijidom, Consultant, Drug Control and Sport Officer African Union Comission (AUC)