1961: The Africa Hall building was formally opened and donated by His Imperial Majesty on behalf of the peoples of Ethiopia to ECA as its Secretariat headquarters. Later this was the venue where the Charter of the Organization of African Unity (OAU) was signed by the Heads of African States when the OAU was inaugurated in 1963.

1964: African Development Bank (AfDB) was established through resolution 96(VI). ECA subregional Office for Eastern and Southern Africa was established in Lusaka at the first Conference of African Planners convened in late 1964 through resolution 104(VI).

1969: Conference of Ministers (COM) established by resolution 188 (IX) as the highest legislative organ of the Commission and composed of the Ministers of Governments of the member States responsible for economic and social development planning.

1975: African Training and Research Centre for Women (ATRCW) established under Conference of Ministers resolution 269 (XII).