Following the launch of the African Continental Free Trade Area (AfCFTA) Anchored Pharmaceutical Initiative (Pharma Initiative) in November 2019, significant milestones have been realized by the United Nations Economic Commission for Africa (ECA) and partners towards building resilient health systems on the continent. The implementation of the Pharma Initiative is anchored on the Africa Medicines Agency (AMA) and AfCFTA, geared towards fostering inclusive and sustainable socioeconomic development through a single market of approximately 1.4 billion people who continually face disproportionate impacts of diseases and high costs of importation of critical life-saving health products. The Pharma Initiative is led by the ECA in partnership with the African Union Commission (AUC), the African Union Development Agency (AUDA-NEPAD), Africa Centres for Disease Control and Prevention (Africa CDC), Intergovernmental Authority on Development (IGAD), and relevant United Nations (UN) agencies – World Health Organization (WHO), United Nations Industrial Development Organization (UNIDO), United Nations Children's Fund (UNICEF), United Nations Population Fund (UNFPA), United Nations Development Coordination Office (UNDCO) and Joint United Nations Programme on HIV/AIDS (UNAIDS).